Cumulative exposure to premenopausal obesity and risk of postmenopausal cancer: A population-based study in Icelandic women
International Journal of Cancer Jan 06, 2020
Noh H, Charvat H, Freisling H, et al. - Researchers intended to determine if there is an association between combined measures of duration and intensity of premenopausal overweight and obesity and the incidence of postmenopausal breast, endometrial, and colorectal cancers in Icelandic women. Using growth curve models, BMI trajectories between ages 20 and 50 of 88,809 women from the Cancer Detection Clinic Cohort were predicted. Incident events of 3,016 postmenopausal breast, 410 endometrial and 987 colorectal cancers have been ascertained during a mean follow-up of 17 years. Cumulative BMI × years of obesity were linearly positively linked to risk of endometrial cancer compared with women who were never obese. On the other hand, the connection with breast cancer was initially positive but leveled off with increasing cumulative BMI × years. Cumulative exposure to obesity may provide additional insights into cancer etiology and should be considered in future studies evaluating the relationship between obesity and cancer.
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