Jones CC, et al. - Researchers assessed cross-cancer pleiotropic associations with the risk of lung cancer in African Americans in this pleiotropic analysis that included 1,410 African American patients with lung cancer and 2,843 control participants. From previous genome-wide association studies, the investigators also analyzed 36,958 variants previously related (or in linkage disequilibrium) to cancer, and they conducted logistic regression analyses in which age, sex, global ancestry, study site, and smoking status were adjusted. On chromosomes 5q14.3, 16q22.2, and 17q12—which include HNF1B, DHODH, and HAPLN1 genes, respectively—new associations were identified. Previously, associations were reported between SNPs within these regions and multiple cancers. For the first time ever, cross-cancer pleiotropic associations for lung cancer in African Americans were studied and identified in this investigation.