Campbell SA, et al. - This cohort study was undertaken to determine if early addition of sitagliptin to metformin was correlated with a delay in T2D progression. To conduct a retrospective cohort study in new metformin users, administrative health records from Alberta, Canada, for the period April 2008 to March 2015, were used. Individuals who began sitagliptin on the same day they initiated metformin therapy were contrasted with those who added sitagliptin later. Of the 8,764 people using sitagliptin, the mean (sd) age was 52.1 (11.1) years, 5,665 (64.6%) were men, and 1,153 (13.2%) began sitagliptin on the same day as metformin. Findings suggested an association of costarting drug therapy with sitagliptin and metformin with a lower possibility of disease progression in T2D people vs adding sitagliptin later.