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Correlation between resistance mechanisms in Staphylococcus aureus and cell wall and septum thickening

Infection and Drug Resistance Oct 27, 2017

García AB, et al. - This study used transmission electron microscopy to assess cell wall and septum thickening of methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), and methicillin- and linezolid-resistant S. aureus (MLRSA) isolates, with an intent to correlate the association of resistance mechanisms with major changes in the morphology of membrane or septum. Researchers correlated the resistance mediated by alterations in the cell membrane of S. aureus (methicillin-resistant, for example) with a greater thickness of the wall or septum. Furthermore, data indicated that the resistance added to linezolid did not determine significant alterations in the characteristics of the wall or septum with respect to those strains resistant only to methicillin.
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