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Correlation between muscle mass and handgrip strength in digestive cancer patients undergoing chemotherapy

Cancer Medicine May 25, 2019

Moreau J, et al. - Researchers assessed the link between muscle mass and handgrip strength (HGS), a secondary aim of FIGHTDIGO study, in digestive cancer patients undergoing chemotherapy. HGS < 30 kg (men) and < 20 kg (women) defined dynapenia (loss of muscle strength). The definition of muscle mass loss was skeletal muscle index (SMI) < 53 cm2/m2 (in men with a body mass index (BMI)> 25 kg/m2), < 43 cm2/m2 (in men with a BMI < 25 kg/m2), and < 41 cm2/m2 (in women irrespective of BMI). This study included 150 patients with mean age 65.6 ± 10.9 years, 58% being males. Of overall cases, 47.3% had colorectal cancer and 76.7% had metastatic stage. Overall 348 Computed Tomography scans were assessed. Findings revealed a strong correlation between the measurements of HGS and SMI. Poor concordance was evident between dynapenia and muscle mass loss.
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