Coronary angiography after cardiac arrest without ST segment elevation: One-year outcomes of the COACT randomized clinical trial
JAMA Sep 05, 2020
Lemkes JS, Janssens GN, van der Hoeven NW, et al. - This study was intended to ascertain if immediate coronary angiography improves clinical outcomes at 1 year in patients after cardiac arrest without signs of ST-segment elevation myocardial infarction (STEMI), compared with a delayed coronary angiography strategy. Researchers designed a prespecified analysis of a multicenter, open-label, randomized clinical trial to analyze 552 patients who were enrolled in 19 Dutch centers between January 8, 2015, and July 17, 2018. Between August 29 and October 10, 2019, the intention-to-treat principle was applied to examine the data. A strategy of immediate angiography was not found to be superior to a strategy of delayed angiography with respect to clinical outcomes at 1 year in this trial of patients successfully resuscitated after out-of-hospital cardiac arrest and without signs of STEMI. In this patient group, coronary angiography can thus be delayed until after neurologic recovery without affecting outcomes.
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