Falasca F, et al. - Researchers evaluated how viremia copy-years (VCY) are correlated with virological failure (defined as a plasma viral load [pVL] >400 copies/mL) and with single levels of viremia. They analyzed 850 antiretroviral therapy (ART)-treated patients with pVL < 37 copies/mL (target not detected or target detected [TD]) or >37, but less than 200 copies/mL (low-level viremia), and at least 6-pVL measures during 54 months of follow-up. Patients with low-level viremia (294 copy-years) displayed higher VCY values than TD (52 copy-years) and target not detected groups (19 copy-years [IQR: 8–54]). VCY is noted to be associated with virological failure and with single levels of viremia, which indicates that minimal residual viremia could cause the cumulative viral burden to increase, in spite of the success of ART. During ART, full viral load suppression is key to limiting the rise in VCY.