Ettinger B, et al. - In this retrospective study, researchers compared the hormone replacement therapy (HRT) continuation rate among women who took cyclic combination therapy adding progesterone to estrogen (CYC-PERT) or continuous combined estrogen progestin therapy (CC-PERT) using a prescription database. They analyzed 1,532 women aged ≥ 45 years who initially filled index prescriptions for 0.625-mg conjugated estrogens. Observations revealed a low likelihood of women continuing HRT beyond 3 years of initiation. Furthermore, CC-PERT users displayed a slightly higher probability of discontinuation vs CYC-PERT users.