Kawamori D, Katakami N, Takahara M, et al. - Since plasma glucagon levels were dysregulated, but significantly associated with serum blood urea nitrogen levels in patients with type 1 diabetes (T1D), researchers examined the annual change in plasma glucagon levels in these same patients. The authors discovered that the plasma glucagon levels in the 66 Japanese patients were significantly correlated between both years. Furthermore, in a multivariate linear regression analysis, as reported in the previous study, they were significantly associated with serum blood urea nitrogen levels. The statistical correlation between annual check-ups in glucagon levels and the sustained significant correlation between glucagon and blood urea nitrogen suggests a constant dysregulation of glucagon in patients with T1D in conjunction with altered amino acid metabolism.