Fan L, Yu A, Zhang D, et al. - This study was carried out to present consequences of HIV/Syphilis coinfection on HIV viral load and immune response to antiretroviral therapy. Researchers designed a retrospective study at Tianjin Second People’s Hospital to investigate the prevalence of syphilis and immune status in 4,171 antiretroviral therapy (ART)-naïve patients. The research enrolled patients who initiated ART between August 2009 and June 2019. This study’s findings demonstrate that HIV/syphilis coinfection had a negative impact on immune recovery and antiretroviral effectiveness. RPR titer and HIV viral load should be monitored in patients co-infected with HIV/syphilis, particularly in patients with high RPR titers.