Yang Y, et al. - Researchers assessed the main mechanisms as well as regulatory issues determining chemosensitivity to oxaliplatin (OXA)-based chemotherapy in hepatocellular carcinoma (HCC). For this purpose, OXA-resistant (OR) HCC cells were developed and real-time RT-PCR, Western blot, immunofluorescence, transwell invasion assay, wound-healing assay, MTT assay, gene transfection, immunohistochemistry was used for analysis. A typical epithelial–mesenchymal transition (EMT) phenotype was demonstrated by OR HCC cells. For HCC cells to obtain EMT-related acquired drug resistance to OXA, a critical factor could be the downregulation of Cx32. OXA resistance in HCC could be overcome by targeting Cx32. In parental HCC cells, EMT induction was the result of downregulation of Cx32 and consequently reduced OXA cytotoxicity, while in OR HCC cells, Cx32 upregulation could reverse the EMT phenotype and partially reestablish chemosensitivity to OXA.