Bainey KR, Engstrøm T, Smits PC, et al. - A systematic review and meta-analysis were performed to ascertain if complete revascularization is correlated with decreased cardiovascular (CV) mortality and if heterogeneity in the association occurs when fractional flow reserve (FFR)- and angiography-guided percutaneous coronary intervention (PCI) strategies for nonculprit lesions are performed. Researchers carried out to search MEDLINE, Embase, ISI Web of Science, and CENTRAL (Cochrane Central Register of Controlled Trials) from database inception to September 30, 2019. They also examined conference proceedings between January 1, 2002, and September 30, 2019. This study enrolled ten randomized clinical trials including a total of 7030 unique patients. The findings revealed that complete revascularization was associated with a reduction in CV mortality compared with culprit-lesion-only PCI, in patients with STEMI and multivessel disease. No differential association with treatment was found between FFR- and angiography-guided strategies on major CV outcomes.