Mehta SR, Wood DA, Storey RF, et al. - Patients (n = 2,016) with ST-segment elevation myocardial infarction (STEMI) and multivessel coronary artery disease who underwent successful culprit-lesion percutaneous coronary intervention (PCI) were randomized to an approach of either complete revascularization with PCI of angiographically important nonculprit lesions or no further revascularization in order to ascertain if PCI of nonculprit lesions further decreases the risk of cardiovascular death or myocardial infarction. In decreasing the risk of cardiovascular death or myocardial infarction, as well as the risk of cardiovascular death, myocardial infarction, or ischemia-driven revascularization among patients with STEMI and multivessel coronary artery disease, complete revascularization was better than culprit-lesion-only PCI.