Liu YJ, Xiao J, Jin HJ, et al. - In this research, the mid-term efficacy of cannulated pedicle screw (CPS) compared to unilateral and bilateral applications in this common lumbar degenerative disease was explored. Researchers enrolled a total of 50 individuals with lumbar spondylolisthesis with osteoporosis who had undergone posterior fixation and fusion using traditional pedicle screws or CPSs between May 2011 and May 2018. Individuals were classified into two groups based on the application: the unilateral PMMA-augmented CPS group (UC, n = 29) and the bilateral PMMA-augmented CPS group (BC, n = 21). The results of this study demonstrate that the unilateral application of PMMA-augmented CPS may serve adequate clinical safety and effectiveness in the surgical treatment of lumbar spondylolisthesis with osteoporosis.