Figueira-Gonçalves JM, et al. - In this retrospective observational study, researchers compared the capability of chronic obstructive pulmonary disease-comorbidity test (COTE) and the non-COPD specific Charlson comorbidity index (CCI) to anticipate all-cause mortality in real-life conditions. This investigation was conducted in 2 consecutive series of COPD patients including 790 and 439 subjects respectively. The COTE and non-age-adjusted CCI indices were calculated and the C-statistic values were compared for both indices to predict all-cause mortality. According to results, the median follow-up was 54 months and 321 deaths occurred within this time period. Investigators found that the C-statistic value for the CCI was significantly higher in both groups than for the COTE index. Overall, they concluded that the value of the CCI to anticipate all-cause mortality in COPD looks higher than that of the COTE index when used in real-life clinical practice.