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Comparison of survival analysis between surgical and non-surgical treatments in duchenne muscular dystrophy scoliosis

The Spine Journal Jun 18, 2020

Yang JH, Kim KS, Lee GH, et al. - A single-center retrospective cohort study was performed to compare the clinical course over time between the patients who were treated surgically and those who were treated non-surgically. Researchers tried to ascertain how surgical treatment could affect the functional status, pulmonary function, and survival rate in patients with duchenne muscular dystrophy (DMD) scoliosis. The clinical data of 199 male patients with DMD scoliosis who were followed up at our center for an average of 6.4 years between 2003 and 2017 were examined. They compared radiologic parameters and Swinyard scale stage between the surgical group and non-surgical group at baseline and 2, 5, and 10 years. This study included a total of 199 patients, 99 patients had undergone the instrumented spinal fusion surgery and 100 patients in the non-surgical group opted for conservative management. The data showed that for DMD scoliosis, spinal surgery improved the forced vital capacity (FVC) for approximately 2 years postoperatively in comparison with non-surgical treatment. Compared with non-surgical group, the surgical group had a better functional status and FVC at baseline. The results demonstrate that the positive impact of surgical treatment on the FVC is owing to scoliosis correction, which delayed the reduce of FVC and consequently extended the survival rate of the individuals with DMD scoliosis.

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