Huo YJ, Thomas R, Li L, et al. - Researchers conducted the study for comparing the diagnostic performance of peripapillary retinal nerve fiber layer (pRNFL) subzones, mean pRNFL thickness, and macular ganglion cell-inner plexiform layer (mGCIPL) in mild, moderate, and severe open-angle glaucoma. For this analysis, 181 patients with open-angle glaucoma (318 eyes: 122 mild, 60 moderate, and 136 severe glaucoma) and 70 normal individuals underwent spectral-domain optical coherence tomography measurements. Compared with glaucoma (67.42 ± 13.22 and 63.31 ± 10.85 μm), mean pRNFL thickness (99.81 ± 10.06 μm) and mGCIPL thickness (83.24 ± 5.91 μm) were higher in controls. In mild and severe glaucoma, mean pRNFL had the best diagnostic performance. The ability of Zone 2 and Zone 4 to detect glaucoma was high and comparable to that of mean pRNFL and mGCIPL across all glaucoma groups.