Noaman S, Dinh D, Reid CM, et al. - Researchers used a multicenter percutaneous coronary intervention (PCI) registry to assess the short- and long-term clinical results of patients with premature coronary artery disease managed by PCI, relative to older cohorts. Participants were 27,869 patients who had PCI from 2005-2017. Patients were split into: young age group (≤ 45 years), middle-age group (46–65 years) and older group (>65 years). Higher rates of in-hospital, 30-day death, and long-term mortality were observed in the young cohort with ST-elevation myocardial infarction (STEMI) vs the non-STEMI subgroup. Lower long-term mortality was shown to be independently predicted by younger age. Overall, findings showed worse prognosis of younger patients presenting with STEMI vs those presenting with non-STEMI. Although there were higher risk presentations among young patients, they experienced a favorable overall prognosis when compared with that of older age groups.