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Comparison of glycemic variability in Chinese T2DM patients treated with exenatide or insulin glargine: A randomized controlled trial

Diabetes Therapy May 25, 2018

Yin TT, et al. - In this prospective study, researchers compared patients on a glucagon-like peptide-1 (GLP-1) receptor agonist with patients on basal insulin in terms of glycemic variability using a continuous glucose monitoring system (CGMS). For 16 weeks, either exenatide treatment or insulin glargine treatment was received by type 2 diabetes mellitus (T2DM) patients treated with metformin. In addition to glycemic variability; hemoglobin A1c (HbA1c), β-cell function, weight, body mass index (BMI), and waist circumference were also assessed. In terms of glycemic variability, HbA1c alleviation, and β-cell function, exenatide and insulin glargine were found to be similarly efficacious in overweight and obese patients with T2DM inadequately controlled by metformin. However, exenatide was shown to have a greater impact on body weight and BMI.
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