Straub SF, et al. - Researchers performed a comparison of dysplastic fundic gland polyps (d-FGPs) in patients with and without familial adenomatous polyposis (FAP), using clinicopathologic findings and β-catenin immunohistochemistry (IHC). On analyzing 124 fundic gland polyps with low-grade dysplasia (LGD) or high-grade dysplasia (HGD) or indefinite for dysplasia (IFD) from 66 patients (27 with FAP; 39 non-syndromic), it was noted that compared to non-syndromic patients, familial adenomatous polyposis patients develop d-FGPs earlier and more often develop additional ones. d-FGPs in FAP and non-syndromic patients displayed similar low rates of β-catenin nuclear IHC positivity. Non-gastric cancers developed in FAP and non-syndromic patients at similar rates, suggesting that d-FGPs may portend a general increased risk of carcinogenesis in non-syndromic patients.