Enzor R, Bowers EMR, Perzia B, et al. - Researchers conducted this retrospective cohort study to compare the outcomes of Pseudomonas aeruginosa keratitis (PAK) in contact lens wearers (CLW) and non-contact lens wearers (non-CLW) and identify risk factors for poor visual acuity (VA) outcomes in each group. Between January 2006 and December 2019, 214 consecutive cases of PAK were involved. In this study, 214 infected eyes were found in 207 PAK patients, with 163 eyes (76.2%) in CLW and 51 eyes (23.8%) in non-CLW. Worse initial VA, older age, a larger size of infiltrate or epithelial defect at presentation, and greater maximal depth of stromal necrosis were among the clinical characteristics that most strongly predicted a poor VA outcome (worse than 20/40) in a machine learning-based study. Non-CLW had slightly worse VA results and involved a higher rate of surgical intervention as compared with CLW. In non-CLW with PAK, the analysis establishes risk factors for poor visual outcomes.