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Comparison of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in patients with diabetes mellitus and non-ST-segment elevation myocardial infarction who underwent successful percutaneous coronary intervention

Atherosclerosis Sep 07, 2018

Byun JK, et al. - Researchers assessed the protective effectiveness of angiotensin-converting-enzyme inhibitors (ACEI) vs angiotensin II receptor blockers (ARB) in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and diabetes mellitus (DM) who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DES). The nationwide Korea Acute Myocardial Infarction Registry enrolled 53,281 patients, of these, 3,426 patients with NSTEMI and DM were treated with renin-angiotensin system inhibitors and had successful PCI with DESs. ACEI showed no beneficial effects in terms of all cause death, cardiac death, or recurrence of MI vs ARB. However, the incidence of revascularization and major adverse cardiac events was reduced with ACEIs in this population.

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