Bruzzone B, De Pace V, Caligiuri P, et al. - Researchers conducted the study for quantifying the performance of different available types of antigen-detecting rapid diagnostic tests (Ag-RDTs) in the real-world hospital setting. They compared the diagnostic performance of seven different Ag-RDTs with the real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) in terms of sensitivity, specificity and expected predictive values. In total, 321 matched Ag-RDT–RT-qPCR samples were analyzed retrospectively. Data reported that the overall sensitivity and specificity of Ag-RDTs were 78.7% and 100%, respectively. According to this retrospective analysis, routine use of Ag-RDTs may be advantageous in moderate-to-high intensity settings where large volumes of specimens are tested on a daily basis. However, the diagnostic performance of commercially available tests can vary significantly.