Fugger G, et al. - This trial examined the connection between major depressive disorder (MDD) and comorbid thyroid disease by comparing patients` characteristics in terms of demographic and clinical information between MDD subjects with and without concurrent thyroid disease using descriptive statistics, analyses of covariance (ANCOVA) and binary logistic regression analyses. Abnormal thyroid function, especially hypothyroidism, exhibited a correlation with depression severity and associated with distinct psychopathologic features of depression. Nonetheless, comorbid thyroid disease did not exert an impact on treatment response. Data disclosed that combination or augmentation of psychopharmacological drugs, especially with antipsychotics, mood stabilizers and pregabalin was more likely in patients with hypothyroid conditions. It was also reported that thyroid disorder was often detected in combination with other chronic somatic diseases including hypertension and heart disease.