Garcia S, et al. - This study draws on data from the National Program of Cancer Registries and the Surveillance, Epidemiology, and End Results Program to assess colorectal cancer (CRC) incidence rates during the period 2001–2014 among Hispanics and non-Hispanic Whites in the United States. For this investigation, they determined incidence rates in younger (age < 50 years) and older (age ≥ 50 years) adults by anatomic subsite and stage at diagnosis, separately for non-Hispanic Whites and Hispanic Whites. It was noted that CRC incidence rates declined among older Whites and Hispanics, but Whites experienced a greater decline. Among younger (age 20–49 years) adults, there were continued increases in CRC incidence from 2001 to 2014. Findings revealed that the largest relative increases in incidence occurred in Hispanics aged 20–29 years. Opposing incidence trends in younger vs older Hispanics might reflect generational differences in CRC risk by birth cohort, as well as environmental exposures and lifestyle-related risk factors correlated with immigration and acculturation.