Guglielmi V, LeCouffe NE, Zinkstok SM, et al. - In a population of patients who had endovascular treatment for large vessel occlusion, researchers tested the assumption patients with ischemic stroke due to cervical carotid atherosclerosis have a more extensive collateral circulation and better outcomes compared with patients with cardioembolism. The sample consisted of consecutive adult endovascular treatment patients (March 2014 to June 2016) with acute ischemic stroke due to anterior circulation large vessel occlusion and compared patients with cervical carotid artery stenosis > 50% to those with cardioembolic etiology from the MR-CLEAN Registry (Multicenter Randomized Controlled Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands). It included 190 patients with cervical carotid atherosclerosis and 476 patients with cardioembolism of 1,627 patients in the Registry. Compared with patients with cardioembolism, those with cervical carotid atherosclerosis were younger (median 69 vs 76 years), more often male (67% vs 47%, P<0.001), more often had an internal carotid artery terminus occlusion (33% vs 18%), and a lower prestroke mRS (mRS score, 0–2; 96% vs 85%. Stroke due to cervical carotid atherosclerosis was linked to higher collateral score and lower median mRS at 90 days compared with cardioembolic stroke. No statistically significant difference was found in the proportion of mRS 0–2 or mortality at 90 days.