Bi X, Song Y, Song Y, et al. - Researchers assessed the formation of enzymatic and nonenzymatic collagen cross‐linking as well as examined its clinical significance among patients suffering from hypertrophic obstructive cardiomyopathy. This analysis involved 44 patients experiencing hypertrophic obstructive cardiomyopathy who had surgical myectomy. Experts assessed cardiovascular magnetic resonance parameters of left atrial/left ventricular function, including peak filling rate and early peak emptying rate. Patients with atrial fibrillation vs those without atrial fibrillation were found to have higher insoluble collagen, insoluble collagen fraction, and advanced glycation end products (AGEs), whereas lysyl oxidase (LOX) expression was similar. Overall, findings indicate a crucial role of collagen cross‐linking on heart remodeling in hypertrophic obstructive cardiomyopathy. An independent correlation of myocardial LOX expression with left ventricular stiffness was identified, while there might be a link between accumulation of AGEs cross‐links and the occurrence of atrial fibrillation in patients suffering from hypertrophic obstructive cardiomyopathy.