Kennedy OJ, Pirastu N, Poole R, et al. - By performing genome-wide association study (GWAS) and Mendelian randomization, researchers investigated the influence of coffee intake on kidney function. They performed a coffee consumption GWAS in 227,666 participants, using UK Biobank baseline data. Data for kidney outcomes for 133,814 participants [12,385 cases of chronic kidney disease (CKD)] of mostly European ancestry across various countries were obtained from CKDGen Consortium. A total of 2,126 single-nucleotide polymorphisms (SNPs) related to coffee consumption were identified, 25 of which were independent and available in CKDGen. Findings revealed that CKD G3-G5 and albuminuria were prevented by drinking an extra cup of coffee per day. After the elimination of 3 SNPs accountable for significant heterogeneity, a higher estimated glomerular filtration rate was observed in relation to an extra cup. Overall, coffee consumption has a beneficial influence on kidney function.