Albéniz E, Álvarez MA, Espinós JC, et al. - Through a single-blind trial at 11 hospitals in Spain from May 2016 through June 2018, comprising of 235 consecutive patients who underwent endoscopic mucosal resection (EMR) for large nonpedunculated colorectal lesions with an average or high risk of delayed bleeding, experts assessed the efficiency of complete clip closure of large (≥ 2 cm) nonpedunculated colorectal lesions following EMR in patients with an estimated average or high risk of delayed bleeding. In the clip group, complete closure was accomplished in 68 cases, along with partial closure in 33 and incompetent close in 18 cases. Delayed bleeding happened in 14 patients in the control group vs six patients in the clip group. There was only one case of delayed bleeding following the completion of the clip closure. Hence, in this randomized trial of individuals with large nonpedunculated colorectal lesions who underwent EMR, it was discovered that clip closure of mucosal defects in patients with a risk of bleeding could be a difficulty, although it also decreases prolonged bleeding. Moreover, the prevention of delayed bleeding needed total clip closure.