Liang D, et al. - In the present study, researchers investigated the clinicopathological features of anti-GBM antibody-negative anti-GBM disease patients. For this investigation, they retrospectively studied the clinical and renal pathological findings in 19 patients. Linear GBM IgG deposition on immunofluorescence(IF), lack of serum anti-GBM antibodies by ELISA and indirect immunofluorescence assay were the criteria for inclusion of all patients. Data reported that hypertension occurred in 68% of cases, nephrotic-range proteinuria (> 3.5 g/24 hours) in 42%, nephrotic syndrome in 37%, microhaematuria in 95%, renal insufficiency in 63% and lung involvement in 16%. Findings revealed that anti-GBM antibody-negative anti-GBM disease was clinically and pathologically different from the classic anti-GBM disease. The pathogenesis of renal injury has not yet been clarified in these patients.