Zhao L, et al. - Using the China National Cancer Center Gastric Cancer Database, researchers compared patients with proximal gastric cancer (PGC) to those with distal gastric cancer (DGC), in terms of clinicopathological characteristics, prognostic factors, and overall survival. This study included 16,119 cases of gastric cancer patients: 6,479 PGC cases and 9,640 DGC cases. Older patients and more males presented with PGC. The chance of being in later pT stage and lymph node metastasis was more in PGC vs DGC. For both PGC and DGC patients, the independent predictors that were found to be related to poor survival were pT4, lymph node metastasis, distant metastasis, no gastrectomy, and Borrmann IV, as revealed in multivariate analysis. Underweight, linitis plastica, and overweight were identified as additional prognostic factors for PGC patients. With regard to clinicopathological features and prognostic factors, significant differences were evident between PGC and DGC in China. However, no significant link between survival outcome and gastric tumor location was identified.