Wang S, Liu Q, Guo F, et al. - Among type 2 diabetes patients with normal renal function, researchers investigated if multivessel coronary artery disease, detected by coronary angiography, could be predicted by serum cystatin C. They also investigated the cutoff point of serum cystatin C for predicting multivessel disease. Participants included 135 consecutive type 2 diabetes patients and 179 nondiabetic patients having normal renal function. Among these, measurements of serum cystatin C levels were obtained via particle-enhanced immunonephelometric assays prior to coronary angiography. Patients with diabetes had a significantly elevated serum cystatin C and the Gensini score. A sensitivity of 67.7% and a specificity of 76.3% was demonstrated by a cystatin C level of 0.865 mg/L, based on the ROC curve, with an AUC of 0.748 in patients with diabetes for detecting multivessel disease. Findings revealed a significant correlation of serum cystatin C with the presence of multivessel disease, this indicates that cystatin C might be applied as a screening tool for multivessel disease prediction among patients with type 2 diabetes mellitus and normal renal function.