Voulgaris T, et al. - Researchers systematically evaluated the performance of the available hepatocellular carcinoma (HCC) risk scores in predicting HCC in chronic hepatitis B (CHB) patients. Until March 2019, they identified the development of 12 scores in untreated Asian and 7 scores in treated Asian (n = 6) or Caucasian (n = 1) patients. Findings suggest that in independent patient cohorts of different origin, direct comparison of the newest HCC risk scores remains intriguing, although statistical correlations may not be directly assignable to clinical practice. In nearly all independent Asian cohorts, acceptable predictability is offered by all scores (c-statistic:0.70-0.86), however, in all independent Caucasian and/or Asian cohorts, only PAGE-B and recently mPAGE-B offered good predictability. Negative predictive values for 5-year HCC prediction were ≤ 99% (95%-99%) in most independent cohorts appraising Asian risk scores and 99%-100% in all independent cohorts (Caucasian/mixed origin:2; Asian:3) evaluating PAGE-B and/or recently mPAGE-B.