Núñez J, Bayés-Genís A, Revuelta-López E, et al. - Researchers investigated a large multicenter cohort of patients with worsening heart failure (HF), either in-hospital or in the outpatient setting, to determine the link between antigen carbohydrate 125 (CA125) and the risk of 1-year clinical results in this patient population. They applied the Royston-Parmar method to examine independent links between CA125 and 1-year death and the composite of death/HF readmission (adjusted for outcome-specific prognostic risk score [BIOSTAT risk score]). For validation, they used the BIOSTAT-CHF (Biology Study to Tailored Treatment in Chronic Heart Failure validation) cohort. The identified independent predictors of CA125 were surrogates of congestion, such as N-terminal pro–B-type natriuretic peptide and composite congestion score. Findings revealed a positive link of higher levels of CA125 with parameters of congestion in this patient sample, and experts noted that CA125 continued to be independently related to a higher risk of clinical results, even beyond a predefined risk model and clinical surrogates of congestion.