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Clinical outcomes of selective vs nonselective His bundle pacing

JACC: Clinical Electrophysiology Jul 19, 2019

Beer D, et al. - Given His bundle pacing (HBP) as the most physiologic form of ventricular pacing and right ventricular septal pre-excitation in correlation to nonselective (NS)-HBP due to fusion with myocardial capture in addition to His bundle capture that results in widened QRS duration compared with selective (S)-HBP wherein there is exclusive His bundle capture and conduction, researchers evaluated the clinical outcomes of NS-HBP compared with S-HBP. From data of 640 patients who underwent successful HBP from the Geisinger and Rush University HBP registries, they analyzed data of 350 consecutive patients treated with HBP for bradyarrhythmic indications and exhibited ≥20% ventricular pacing burden 3 months post-implantation. In the NS-HBP group, they identified a higher number of men (64% vs 50%), higher incidence of infranodal atrioventricular block (40% vs 9%), ischemic cardiomyopathy (24% vs 14%), and permanent atrial fibrillation (18% vs 8%). Outcomes of death or heart failure hospitalization were comparable between the groups.
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