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Clinical outcomes of allogeneic ocular surface stem cell transplantation in pediatric patients

Cornea Dec 04, 2020

Cheung AY, Sarnicola E, Eslani M, et al. - In this retrospective interventional case series from a single tertiary referral institution, researchers sought to characterize the outcomes of allograft ocular surface stem cell transplantation (OSST) and the complication profile of systemic immunosuppression (SI) in pediatric patients with limbal stem cell deficiency. The sample consisted of 13 patients (20 eyes) who underwent allograft OSST surgery, who were 18 years or less at time of OSST, and who received SI with a minimum of 12-months follow-up. Data reported that the mean age of patients was 15.1 ± 3.2 years and the mean follow-up was 5.6 ± 5.0 years after OSST. For pediatric patients with limbal stem cell deficiency, OSST offers a stable ocular surface and is a promising treatment choice. SI was well tolerated in all patients with few adverse events.

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