Camanho LEM, et al. - Researchers conducted this study in order to assess how advanced age influence clinical response and cardiovascular and total mortality of patients undergoing cardiac resynchronization therapy (CRT). Further, they investigated the rate of acute complications related to the procedure. CRT was undertaken in a total of 249 consecutive patients with heart failure (HF) and optimized treatment, QRS ≥ 120 ms, ejection fraction ≤ 35% and functional class (FC) III/ IV (NYHA); these patients were divided into three groups: Group I—< 65 years—88/ 249 (35%); Group II– 65 to 75 years (old)– 72/ 249 (29%); Group III—≥ 75 years (very old)– 89/ 249 (36%). Outcomes revealed no effect of advanced age on the response to CRT and cardiovascular mortality and hence it should not be an exclusion factor of this therapy. Elderly patients had low rate of acute complications with the procedure supporting its safety in this population.