Singh M, et al. - In this single-centre retrospective hospital-based study, researchers described the presentation and prognosis of adrenal histoplasmosis (AH) and cortisol status before and after antifungal therapy. Between 2006 and 2018, 40 consecutive adults with AH were studied. After one year of antifungal therapy, no patient with primary adrenal insufficiency (PAI) became eucortisolemic on re-testing. Investigators found that all patients with AH tested negative for HIV antibody. Although patients achieved a high rate of clinical remission after antifungal therapy, the overall mortality rate was significant. Despite treatment, cortisol insufficiency did not normalize.