Sujino Y, Nakano S, Tanno J, et al. - Given the existence of a lack of clarity about the clinical influence of a high blood urea nitrogen (BUN)/creatinine ratio at discharge with respect to renal dysfunction, neurohormonal hyperactivity, and different responsiveness to decongestion therapy in acute decompensated heart failure (ADHF) cases, researchers investigated the predictive value of a high BUN/creatinine ratio at discharge as well as its haemoconcentration-dependent influences in patients with ADHF in a multicentre, prospective cohort registry-based study, named the West Tokyo Heart Failure registry. Post-discharge all-cause death was assessed as the endpoint. Findings revealed an independent link of a higher BUN/creatinine ratio at discharge with higher post-discharge all-cause mortality in patients with ADHF. As for a high BUN/creatinine ratio at discharge, they reported that its predictive value was found to be haemoconcentration dependent and it was suggested as a possible unfavourable predictor in patients displaying excessive haemoconcentration and haemodilution, but not in those exhibiting modest haemoconcentration/haemodilution.