Kim JY, Kang D, Nam SJ, et al. - Researchers analyzed a modern BC registry including subtypes and treatment information to determine the clinical features and outcomes of invasive breast cancer (BC) among different age groups. In this retrospective cohort study, they assessed 6,405 women (aged 18 years or older) who had pathologically confirmed stage I, II, or III BC and had undergone curative surgery followed by adjuvant therapy at a university-based hospital in Seoul, South Korea, between January 2003 and December 2011. Reports of 256 deaths were identified during 36,360 person-years of follow-up (mortality rate, 7.0/1,000 person-years). They identified a strong J-shaped relationship between age and mortality, intimating worse clinical outcomes in young and old patients. Increased risk of mortality was observed across age groups in correlation with advanced stage at diagnosis, luminal type as well as triple-negative BC, and not receiving adjuvant treatment were associated. A possible benefit of personalized BC screening examination and precise and active treatment strategies may aid in reducing BC-related mortality.