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Clinical characteristics and predictors of mortality in patients with candidemia: A six-year retrospective study

European Journal of Clinical Microbiology & Infectious Diseases Aug 27, 2018

Jia X, et al. - Researchers performed a retrospective study of hospitalized patients with candidemia in southwest China to examine the differences in candidemia episodes between ICU and surgical wards or the correlation between serum biomarkers and mortality from candidemia. ICU patients were more frequently subjected to extensive invasive procedures, severe clinical presentations, and heavy exposure to antibiotics compared with surgical patients. In addition, ICU patients had significantly higher mortality than those in the surgical wards. As per the multivariable analysis, independent factors associated with mortality include ascites, catheter-related candidemia, ICU admission, septic shock, and concomitant bacterial infection. Moreover, mortality from candidemia was identified to be associated with high PCT and BDG levels as well as low PLT counts. Identification of specific predictors in different wards could allow the recognition of high-risk candidates to receive early antifungal therapy, thus enhancing the outcomes of critically ill patients with candidemia.
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