Wu MT, et al. - Among 409 initially diagnosed hepatocellular carcinoma (HCC) [most common causes of cancer-related death worldwide] patients, researchers studied the prognostic performance of pretreatment albumin to C-reactive protein ratio (ACR). Cox regression with log-rank testing has been used to evaluate overall survival (OS) and disease-free survival (DFS), and Kaplan-Meier curves have been used to predict HCC patient prognosis. Independent factors for OS in HCC patients were treatment exposure, tumor size, serum alpha-fetoprotein (AFP) level, and TNM stage. Independent factors for DFS in HCC patients were treatment exposure, TNM stage, serum AFP level, tumor size, and ACR. For HCC patients predicting OS and DFS, pretreatment ACR is a convenient and useful parameter. Findings suggested an association of lower ACR with advanced TNM stage, larger tumor size, and a high concentration of AFP. These outcomes can help design strategies for customizing HCC patient management approaches.