Du Q, et al. - In this investigation, researchers analyzed the regulation and activity of the circRNA-miRNA-mRNA axis in nonfunctioning pituitary adenomas (NFPAs), major cause of hypopituitarism and infertility, tumorigenesis. In vitro and vivo, the function of miR-145-5p in NPFAs was investigated. Based on the results of this study, CircOMA1 promotes the progression of NFPAs by acting as a tumor suppressor sponge miR-145-5p to regulate the translationally controlled tumor protein (TPT1) signaling pathway, showing a new therapeutic target for the prevention of NFPA tumorigenesis.