Shi Y, Sun M, Wang Z, et al. - By performing this cross-sectional analysis, researchers examined the link between cholecystectomy and the factors associated with glycemia and glucose tolerance. This inquiry was conducted in Nanjing, China, and included 10,027 participants aged ≥ 40. Following elimination, 8,030 participants remained who were split into three groups: 1, without gallbladder disease (n = 6,783); 2, with gallbladder disease but without cholecystectomy (n = 857); and 3, with cholecystectomy (n = 390). A higher prevalence of newly diagnosed diabetes using oral glucose tolerance test criteria was revealed in Group 3 vs groups 2 and 1. For diabetes related to cholecystectomy, the adjusted odds ratio and 95% confidence interval were estimated to be 1.546 (1.168, 2.046). Following adjustment for confounding factors, group 3 vs the other two groups demonstrated a higher total insulin release and lower Matsuda insulin sensitivity index. Overall, a higher prevalence of diabetes characterized by lower peripheral insulin sensitivity and higher total insulin release was identified among cholecystectomized individuals.