Pitasi M, et al. - Data from 506 transgender women (1045 total visits) and 120 transgender men (209 total visits) who attended 26 publicly funded clinics that provide sexually transmitted disease (STD) services in 6 US cities during a 3.5-year observation period were analyzed to determine the proportion of transgender women and transgender men who tested positive for urogenital and extragenital chlamydial or gonococcal infections and who self-reported or tested positive for human immunodeficiency virus (HIV) infection during the observation period. As per findings, 13.1% of the transgender women tested positive for chlamydia and 12.6% tested positive for gonorrhea at 1 or more anatomic sites, and 14.2% were HIV-infected. Among the transgender men, 7.7% and 10.5% tested positive for chlamydia and gonorrhea at 1 or more anatomic sites, and 8.3% were HIV-infected. A negative urogenital test at the same visit was observed in majority of transgender women (86.0% and 80.9%, respectively) and more than a quarter of transgender men (28.6% and 28.6%, respectively) with an extragenital chlamydial or gonococcal infection. For transgender persons, publicly funded clinics providing STD services seem to be a significant source of STD care.