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Changes in the homeostatic appetite system after weight loss reflect a normalization towards a lower body weight

Journal of Clinical Endocrinology and Metabolism Apr 22, 2020

DeBenedictis JN, Nymo S, Ollestad KH, et al. - Researchers conducted the study for comparing appetite markers in reduced-obese people with a non-obese control group. Thirty-four adults with obesity who lost 17% body weight at week 13 and maintained this weight loss (WL) at 1 year were contrasted with 33 non-obese controls matched for body composition. According to findings, the increased appetite for food (both subjective feelings of hunger and ghrelin concentrations) seen in reduced-obese people, both after acute and sustained WL, represents a normalization towards a lower body weight. Overall, WL has no sustained negative impact on satiety peptide secretion despite the blunt secretion in individuals with obesity vs non-obese controls.

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