Jensen MT, Fung K, Aung N, et al. - Among participants from the UK Biobank Cardiovascular Magnetic Resonance Substudy, researchers determined early changes in cardiac structure and function related to diabetes mellitus (DM), by means of cardiovascular magnetic resonance imaging. The participants were without recognized cardiovascular disease and left ventricular ejection fraction ≥ 50%. They performed multivariable linear regression models. They found significantly smaller left ventricular (LV) and right ventricular volumes, lower left atrial and right atrial emptying fraction, as well as impaired LV global circumferential strain in DM. Findings revealed the link of DM with early alterations in all 4 cardiac chambers in a low-risk general population without known cardiovascular disease and with preserved LV ejection fraction. This indicates a global involvement of the heart in diabetic cardiomyopathy, rather than regional LV involvement.