Hoffmann A, et al. - Researchers investigated cerebral blood flow modulations during proactive and reactive cognitive control in major depressive disorder (MDD). They assessed blood flow in the middle cerebral arteries in a precued Stroop task among 40 MDD patients and 40 healthy controls using functional transcranial Doppler sonography. Prolonged response times were observed among patients, reflecting general mental slowing. During task preparation, blood flow reduced and during its execution blood flow enhanced. Reduced proactive and elevated reactive control might characterize depression.