Shinojima A, et al. - Researchers conducted this investigation to evaluate risk factors for serous retinal detachment (SRD) in fellow eyes of central serous chorioretinopathy (CSC) patients based on clinical information and multimodal imaging results, including baseline late-phase indocyanine green angiography (ICGA). They retrospectively evaluated consecutive patients with unilateral CSC. Using Kaplan-Meier survival curves (log-rank test), baseline medical data and multimodal imaging findings were analyzed. Participants in the study were 68 patients with unilateral CSC. During a mean follow-up of 25.8 ± 18.7 months, an SRD was identified in 19% of fellow eyes. The occurrence of SRD was correlated with hyperfluorescent plaques on midphase ICGA, hypofluorescent foci on late-phase ICGA, retinal pigment epithelium changes on fundus autofluorescence and fluorescein angiography abnormalities. These findings indicate that the fellow eyes in patients with unilateral CSC should be closely monitored for possible incidence of CSC with particular findings on multimodal imaging.