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CD163+ macrophages predict a poor prognosis in patients with primary T1 high-grade urothelial carcinoma of the bladder

World Journal of Urology Mar 19, 2019

Yang G, et al. - Researchers assessed 94 T1 high-grade (T1HG) bladder cancer samples to study the prognostic importance of tumor-infiltrated CD163+ macrophages in these cases. They observed 39.4% of these patients suffered disease recurrence, 14.9 suffered progression of disease, and 11.7% suffered disease-specific mortality within a median follow-up of 60 months. A link between high CD163+ macrophages and a higher risk of both disease recurrence and progression was also recorded. They suggested high CD163+ macrophages as a significant negative predictor of recurrence-free survival, progression-free survival, and disease-specific survival.

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